Virulence of Avian Influenza A Viruses for Squirrel Monkeys
Identifieur interne : 002630 ( Main/Exploration ); précédent : 002629; suivant : 002631Virulence of Avian Influenza A Viruses for Squirrel Monkeys
Auteurs : Brian R. Murphy ; Virginia S. Hinshaw [États-Unis] ; D. Lewis Sly [États-Unis] ; William T. London [États-Unis] ; Nanette T. Hosier ; Frank T. Wood ; Robert G. Webster [États-Unis] ; Robert M. ChanockSource :
- Infection and Immunity [ 0019-9567 ] ; 1982.
Abstract
Ten serologically distinct avian influenza A viruses were administered to squirrel monkeys and hamsters to compare their replication and virulence with those of human influenza A virus, A/Udorn/307/72 (H3N2). In squirrel monkeys, the 10 avian influenza A viruses exhibited a spectrum of replication and virulence. The levels of virus replication and clinical response were closely correlated. Two viruses, A/Mallard/NY/6874/78 (H3N2) and A/Pintail/Alb/121/79 (H7N8), resembled the human virus in their level and duration of replication and in their virulence. At the other end of the spectrum, five avian viruses were restricted by 100- to 10,000-fold in replication in the upper and lower respiratory tract and were clearly attenuated compared with the human influenza virus. In hamsters, the 10 viruses exhibited a spectrum of replication in the nasal turbinates, ranging from viruses that replicated as efficiently as the human virus to those that were 8,000- fold restricted. Since several avian viruses were closely related serologically to human influenza viruses, studies were done to confirm the avian nature of these isolates. Each of the avian viruses plaqued efficiently at 42°C, a restrictive temperature for replication of human influenza A viruses. Avian strains that had replicated either very efficiently or very poorly in squirrel monkeys still grew to high titer in the intestinal tracts of ducks, a tropism characteristic of avian, but not mammalian, influenza viruses. These observations indicate that some avian influenza A viruses grow well and cause disease in a primate host, whereas other avian viruses are very restricted in this host. These findings also provide a basis for determining the gene or genes involved in the restriction of replication that is observed with the attenuated avian viruses. Application of such information may allow the preparation of reassortant viruses derived from a virulent human influenza virus and an attenuated avian virus for possible use in a live attenuated vaccine for prevention of influenza in humans.
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PubMed: 7129631
PubMed Central: 347656
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Murphy</name><affiliation><nlm:aff id="af1">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease</nlm:aff><wicri:noCountry code="subfield">National Institute of Allergy and Infectious Disease</wicri:noCountry></affiliation></author><author><name sortKey="Hinshaw, Virginia S" sort="Hinshaw, Virginia S" uniqKey="Hinshaw V" first="Virginia S." last="Hinshaw">Virginia S. Hinshaw</name><affiliation wicri:level="2"><nlm:aff id="af3">Division of Virology, St. Jude Children's Hospital, Memphis, Tennessee 28101</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Virology, St. Jude Children's Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Sly, D Lewis" sort="Sly, D Lewis" uniqKey="Sly D" first="D. Lewis" last="Sly">D. 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Hosier</name><affiliation><nlm:aff id="af1">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease</nlm:aff><wicri:noCountry code="subfield">National Institute of Allergy and Infectious Disease</wicri:noCountry></affiliation></author><author><name sortKey="Wood, Frank T" sort="Wood, Frank T" uniqKey="Wood F" first="Frank T." last="Wood">Frank T. Wood</name><affiliation><nlm:aff id="af1">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease</nlm:aff><wicri:noCountry code="subfield">National Institute of Allergy and Infectious Disease</wicri:noCountry></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation wicri:level="2"><nlm:aff id="af3">Division of Virology, St. Jude Children's Hospital, Memphis, Tennessee 28101</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Virology, St. Jude Children's Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation><nlm:aff id="af1">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease</nlm:aff><wicri:noCountry code="subfield">National Institute of Allergy and Infectious Disease</wicri:noCountry></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1982">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Ten serologically distinct avian influenza A viruses were administered to squirrel monkeys and hamsters to compare their replication and virulence with those of human influenza A virus, A/Udorn/307/72 (H3N2). In squirrel monkeys, the 10 avian influenza A viruses exhibited a spectrum of replication and virulence. The levels of virus replication and clinical response were closely correlated. Two viruses, A/Mallard/NY/6874/78 (H3N2) and A/Pintail/Alb/121/79 (H7N8), resembled the human virus in their level and duration of replication and in their virulence. At the other end of the spectrum, five avian viruses were restricted by 100- to 10,000-fold in replication in the upper and lower respiratory tract and were clearly attenuated compared with the human influenza virus. In hamsters, the 10 viruses exhibited a spectrum of replication in the nasal turbinates, ranging from viruses that replicated as efficiently as the human virus to those that were 8,000- fold restricted. Since several avian viruses were closely related serologically to human influenza viruses, studies were done to confirm the avian nature of these isolates. Each of the avian viruses plaqued efficiently at 42°C, a restrictive temperature for replication of human influenza A viruses. Avian strains that had replicated either very efficiently or very poorly in squirrel monkeys still grew to high titer in the intestinal tracts of ducks, a tropism characteristic of avian, but not mammalian, influenza viruses. These observations indicate that some avian influenza A viruses grow well and cause disease in a primate host, whereas other avian viruses are very restricted in this host. These findings also provide a basis for determining the gene or genes involved in the restriction of replication that is observed with the attenuated avian viruses. Application of such information may allow the preparation of reassortant viruses derived from a virulent human influenza virus and an attenuated avian virus for possible use in a live attenuated vaccine for prevention of influenza in humans.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Tennessee</li></region></list><tree><noCountry><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><name sortKey="Hosier, Nanette T" sort="Hosier, Nanette T" uniqKey="Hosier N" first="Nanette T." last="Hosier">Nanette T. Hosier</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Wood, Frank T" sort="Wood, Frank T" uniqKey="Wood F" first="Frank T." last="Wood">Frank T. Wood</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Hinshaw, Virginia S" sort="Hinshaw, Virginia S" uniqKey="Hinshaw V" first="Virginia S." last="Hinshaw">Virginia S. Hinshaw</name></region><name sortKey="London, William T" sort="London, William T" uniqKey="London W" first="William T." last="London">William T. London</name><name sortKey="Sly, D Lewis" sort="Sly, D Lewis" uniqKey="Sly D" first="D. Lewis" last="Sly">D. Lewis Sly</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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